The Farrar Lab is in the Department of Laboratory medicine and Pathology
(LMP) at the University of Minnesota Medical School. Our lab is part of the
Center for Immunology and Masonic Cancer Center, located in the
Winston and Maxine Wallin Medical Biosciences Building (WMBB) on the
Twin Cities campus.
Work in the Farrar Lab is focused on lymphocyte differentiation and
function. We are pursuing this via three main areas of investigation. First,
we have a long-standing interest in the development and function of
regulatory T cells, which play a key role in preventing autoimmune
disease, imprinting tolerance to commensal organisms, and reducing
inflammation following infections. Second, we have been investigating the
genetic circuits that regulate B cell development and exploring how
mutations that affect these circuits drive B cell transformation in mice and
humans. Third, and most recently, we have been tracking the CD4 T cell
immune response to B cell leukemia and examining how combination
chemotherapy and immunotherapy synergize to eliminate leukemia. We
using cutting edge single-cell technologies, spatial transcriptomics/
proteomics and novel mouse models to explore these questions.
